Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 pathology and cytotoxicity. suggesting the involvement of aberrant expression of TDP-43 in the pathogenesis of ALS. In normal conditions. https://macorners.shop/product-category/wood-message-frame/