Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune responses. Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pathways. The two naturally occurring forms of BPLF1 exerted potent suppressive effect on cGAS-STING-. RIG-I- and TBK1-induced IFN production. https://www.chiggate.com/to-the-moon-jarretel-catsuit-neon-pink-hot-on-sale/